Epidermolysis Bullosa Clinic Clinical Trials
A Randomized, Double-Blind, Placebo-Controlled, Dose-Response Study of the Safety and Efficacy of Thymosin Beta 4 in the Treatment of Patients with Epidermolysis Bullosa
Patients with Junctional or Dystrophic Epidermolysis Bullosa are being sought for a wound healing research study to test the safety and wound healing properties of Thymosin Beta 4 (Tβ4) in EB wounds. Tβ is a naturally occurring substance present in human cells. It represents a new class of wound healing drug.
This is a Double-Blind, Placebo-Controlled study, which means that some patients will receive a gel with medicine (Tβ4) in it and some will receive a gel with no medicine in it (placebo). Neither the patient nor the Study Doctor will know which medicine the patient receives. Patients have a 75% chance of receiving study drug. (For every 3 patients who receive the gel with medicine, 1 patient will receive the gel without medicine.)
The study medication gel (Tβ4 or Placebo) will be placed once a day on a single lesion (a sore selected by the doctor for treatment). Study medication will be used each day until the lesion heals or for up to 8 weeks, whichever comes first. Study patients are required to see the Study Doctor every other week for up to a total of 6 visits.
The EB wound will be examined and photographed at each visit. Blood will be drawn at study start, at 2 weeks, at 4 weeks, at 8 weeks and at the follow-up visit. If the lesion heals before 8 weeks, blood work will be done fewer times and fewer study visits will be required.
Patients receive either $50 per visit or reimbursement for travel expenses, whichever is greater.
Detailed information on the above study
If you are interested in participating in our clinical trial studies, please contact Andrea Tichy at (650) 721-7166 or email her at
for more information.
For further information regarding questions, concerns, or complaints about research, research related injury, and questions about the rights of research participants, please call (650) 723-5244 or call toll free 1-866-680-2906, or write the Administrative Panel on Human Subjects in Medical Research, Administrative Panels Office, Stanford University, Stanford, CA 94305-5401.
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